Drugs to be Discontinued: Mebaral (mephobarbital) 32mg tablets, 50mg tablets and 100mg tablets (updated)

Drug NameCompanyInformationRelated InformationAgenerase (amprenavir) 150mg capsule


updated
10/10/2007

GlaxoSmithKline
888-825-5249

 

Letter from GlaxoSmithKline (updated 10/10/2007)

5%Alcohol in 5% Dextrose Injection, USP, Glass Container

12/19/2007

Hospira, Inc.
877-946-7747Hospira has made a business decision to discontinue manufacturing of 5% Alcohol in 5% Dextrose Injection drug product (NDC# 0409-1500-05)

Brevibloc Concentrate (esmolol HCl) 250 mg/mL, 10 mL ampul

8/24/2007

Baxter Healthcare CorporationBaxter Healthcare Corporation has made a decision to discontinue Brevibloc Concentrate (esmolol HCl) 250 mg/mL, 10 mL ampul (NDC 10019-025-18 for the pack and NDC 10019-025-73 for the ampul). Letter from Baxter

Calciferol injection in oil (ergocalciferol)

3/19/2004

Schwarz Pharma
6140 W. Executive Drive
Mequon, WI 53092
800-558-5114
 Schwarz has discontinued manufacturing of calciferol
 

CEFOTAN (cefotetan injection)

6/9/2006

AstraZeneca Pharmaceuticals LP (AstraZeneca) - Contact Corporate Information Center at 800-236-9933.The remaining inventory of CEFOTAN (cefotetan
injection) has been depleted. AstraZeneca has no further plans to manufacture or distribute CEFOTAN (cefotetan injection). Other cefotetan injection products continue to be available.
 

Cortisporin Ophthalmic Suspension (neomycin and polymyxin B sulfates and hydrocortisone ophthalmic suspension)

6/5/2008

King Pharmaceuticals
800-776-3637Letter from King Pharmaceuticals  

Cortisporin Otic Suspension (neomycin and polymyxin B sulfates and hydrocortisone otic suspension, USP) 

6/5/2008

King Pharmaceuticals
800-776-3637Letter from King Pharmaceuticals  

Cylert (pemoline) tablets and chewable tablets, all strengths

5/25/2005
 

Abbott Laboratories
 

Abbott has made the decision to discontinue Cylert tablets and chewable tablets

Letter from Abbott

Cytoxan (cyclophosphamide) 25mg and 50mg tablets

9/24/2007

Bristol-Myers Squibb Company
609-897-2412Bristol-Myers Squibb Company has made a decision to discontinue Cytoxan (cyclophosphamide) 25mg and 50mg tablets. Alternate products continue to be available from other companies.

Desyrel (trazodone) Tablets 50mg, 100mg, 150mg and 300mg tablets

9/21/2006

Bristol-Myers Squibb Company
609-897-2412

Alternate products continue to be available from other companies.

Dear Healthcare Professional Letter

ELAVIL (amitriptyline hydrochloride) Tablets and Injection.

 

5/15/2003

AstraZeneca Pharmaceuticals LP (AstraZeneca) – Contact Corporate Information Center at:
800-236-9933ELAVIL Injection is no longer available at AstraZeneca. The remaining inventory of ELAVIL Tablets will be depleted by December 31, 2003. AstraZeneca has no further plans to manufacture ELAVIL (amitriptyline hydrochloride) Tablets or Injection.Ephedrine Sulfate Injection 50mg/ml (NDC 00409-3073-31)2/8/2011
 Hospira, Inc.
1-877-946-7747Hospira has made a business decision to discontinue manufacturing this product.  Akorn and Sandoz continue to have product available.
Dear Valued Customer Letter (PDF - 70KB)
 

Ethmozine (moricizine hydrochloride) 200mg, 250g, and 300mg tablets

9/17/2007

Shire US Inc.
725 Chesterbrook Blvd.
Wayne, Pa 19087
1-800-828-2088Dear Healthcare Professional Letter

Exubera (insulin recombinant human, powder for inhalation)

10/19/2007

Pfizer
800-398-2372Dear Healthcare Provider Letter

Faslodex* (fulvestrant) Injection, 2.5 ml (2 x 2.5 ml pre-filled syringe), (125 mg /2.5 ml (50 mg/ml) FASLODEX intramuscular injection), NDC 0310-0720-2510. Faslodex (fulvestrant) Injection: one 5.0 ml syringe (250mg/5ml), NDC 0310-0720-50

updated
1/14/2011

 

AstraZeneca Pharmaceuticals LP (AstraZeneca)

Contact the Corporate Communication Center at 1-800-236-9933

There is no remaining inventory within AstraZeneca's distribution network. The final expiration date of any Faslodex* (fulvestrant) Injection that may still be remaining in the market place is December 31, 2010.

AstraZeneca is discontinuing supply of the single dose pack. Inventory depletion is expected the week of Jan 17, 2010. The dual dose pack (NDC 0310-0720-10), two 5.0ml syringes (250mg/5ml) continues to be available.

Florinef (fludrocortisone acetate tablets, USP)

6/8/2007

King Pharmaceuticals, Inc. 501 Fifth Street Bristol, Tennessee 37620 Professional Information Services Department:
800-776-3637Dear Healthcare Provider Letter

Flovent Rotadisk (fluticasone propionate inhalation powder)

8/31/2004

GlaxoSmithKline
888-825-5249Please see Dear Healthcare Professional letter for additional information.
 

Fortovase (saquinavir) capsules 200 mg

6/2/2005

Roche

Fortovase 200 mg capsules will be discontinued by February 15, 2006. Please see attached DHP letter for additional information.

Dear Healthcare Professional Letter
 

Foscavir (foscarnet sodium) injection

10/31/2008

AstraZeneca Pharmaceuticals LP (AstraZeneca)

Contact Corporate Information Center at 1-800-236-9933
 

The remaining inventory of Foscavir (foscarnet sodium) injection will be depleted by April 30, 2009. AstraZeneca has no further plans to manufacture or distribute Foscavir (foscarnet sodium) injection after April 30, 2009.

 

Geocillin (carbenicillin indanyl sodium) tablets 382 mg

4/8/2008

PfizerPfizer has discontinued this product. There are no other FDA approved manufacturers currently for carbenicillin tablets.

Geref Diagnostic (sermorelin acetate for injection) 0.05mg base/amp
 

8/5/2008

EMD Serono
1-888-398-4567

EMD Serono has made a business decision to discontinue this product.

Dear Healthcare Professional Letter
 

Heparin Sodium in 5% Dextrose premix product3/18/2011
 Baxter Customer Service:
(1-888-229-0001)Heparin Sodium and 0.9% Sodium Chloride Injection product remains available.
 
Dear Valued Baxter Customer Letter (PDF - 29KB)

Humatin (Paromomycin Sulfate Capsules, USP)

 

2/7/2008

King Pharmaceuticals Professional Information Services Department
800-776-3637

King Pharmaceuticals has made a decision to discontinue Humatin (Paromomycin Sulfate Capsules, USP) Paromomycin continues to be available from another manufacture.

 

Letter from King Pharmaceuticals

Humulin 50/50 Insulin
 

updated
10/26/2010

 

Eli Lilly and Company
1-800-545-5979

Dear Healthcare Professional Letter (PDF - 201KB)

Patient Information (PDF - 887KB)

Humulin U ULTRALENTE (HUMAN INSULIN [rDNA ORIGIN] EXTENDED ZINC SUSPENSION)

7/6/2005

Eli Lilly and Company

Dear Doctor Letter

Patient Information

Humulin L LENTE (HUMAN INSULIN [rDNA ORIGIN] ZINC SUSPENSION)

7/6/2005

 Eli Lilly and Company

Dear Doctor Letter

 

Patient Information

 

HIVID (zalcitabine) tablets

7/26/2006

Roche Pharmaceuticals

The sale and distribution of its anti-HIV
medication HIVID (zalcitabine) Tablets will be discontinued by December 31, 2006.

Dear Health Care Professional Letter

Intal Inhaler (cromolyn sodium inhalation aerosol)

8/3/2009

King PharmaceuticalsDear Healthcare Professional Letter

Intal Nebulizer Solution (cromolyn sodium inhalation solution, USP)

6/2/2008

King Pharmaceuticals
800-776-3637Letter from King Pharmaceuticals

Inversine (mecamylamine hydrochloride) Tablets, 2.5 mg

6/17/2009

Targacept, Inc.
336-480-2100Dear Healthcare Professional Letter

Inulin in Sodium Chloride Injection, USP

9/26/2003
 

Questcor Pharmaceuticals, Inc.Letter

Kefzol (cefazolin) all presentations

2/28/2003

Eli Lilly and CompanyLetter

Kefurox (cefuroxime) all presentations

2/28/2003

Eli Lilly and CompanyLetter

Kemadrin (procyclidine hydrochloride)

6/6/2008

King Pharmaceuticals
800-776-3637Letter from King Pharmaceuticals  

Lanoxin Elixir(digoxin)

6/3/2005

GlaxoSmithKlineThis product has been discontinued by GSK.
Roxane is producing digoxin elixir.
 

LEXXEL (enalapril maleate-felodipine ER) Tablets

12/19/2007

AstraZeneca LP (AstraZeneca) - Contact Corporate Information Center at

800-236-9933.

LEXXEL Tablets will be discontinued on July 31, 2008. AstraZeneca has no further plans to manufacture or distribute LEXXEL (enalapril maleate-felodipine ER) Tablets after July 31, 2008.

Lorabid(loracarbef, USP) capsules and suspension

10/27/2006

King Pharmaceuticals 888-840-5370Letter from King Pharmaceuticals

Mandol (cefamandole) all presentations

2/28/2003

Eli Lilly and CompanyLetterMebaral (mephobarbital) 32mg tablets, 50mg tablets and 100mg tablets1/6/2012
 

Lundbeck Inc. Customer service number:
1-888-514-5204

Lundbeck is no longer able to manufacture Mebaral CIV (brand of mephobarbital tablets, USP), and the company's remaining inventory will expire in March 2012. Due to product expiration, we will not be able to make any product shipments after February 29, 2012. Once this current stock of Mebaral is depleted, the product will no longer be available.

Lundbeck is aware of the difficult situation that some patients may face with regard to the upcoming Mebaral discontinuation. The company thoroughly evaluated all avenues for keeping Mebaral available to patients, but ultimately concluded that no matter what steps we took, patients would be forced to transition to a new therapy. Due to the limited remaining Mebaral supply, we encourage patients to work with their physician to transition to alternative therapies rather than starting a new course of therapy with Mebaral. For more information or with questions, Lundbeck’s medical information team can be reached at 866-402-8520.

Mebendazole Tablets10/26/2011Teva Pharmaceuticals1-800-545-8800Dear Valued Customer Letter (PDF - 43KB)

Mitozytrex (Mitomycin for Injection)

9/12/2008

SuperGen

(925) 560-0100
 

Other Mitomycin approved products continue to be available.

This product was never commercialized.

 

Mivacron (mivacurium chloride) injection

6/23/2006

Abbott LaboratoriesAlternative products that can be used in place of Mivacron continue to be available. Please call Abbott at 1-800-633-9110 for additional information.

 

Moban (molindone hydrochloride)
5 mg, 10 mg, 25 mg, and 50 mg Tablets

1/13/2010

Endo Pharmaceuticals Inc.
1-800-462-ENDO (1-800-462-3636)Moban tablets have been discontinued and supplies are anticipated to be depleted by June 30, 2010.

Nandrolone Decanoate Injection

6/24/2009

Watson Pharmaceuticals
(800) 272-5525Watson Pharmaceuticals has discontinued this product because of the unavailability of the active pharmaceutical ingredient.

Neutrexin (trimetrexate glucuronate) Injection

6/14/2007

MedImmune, Inc.Dear Healthcare Professional Letter

Nimotop (nimodipine) capsules

10/31/2008

Bayer HealthCare Pharmaceuticals
888-842-2937

Generic nimodipine remains available.

Please see Dear Healthcare Professional Letter  for additional information.
 

 

Nolvadex (tamoxifen citrate)

4/10/2006
 

AstraZeneca
800-236-9933Letter

Novolin InnoLet disposable pens and Novolin PenFill 3 mL cartridges for Novolin R, N and 70/30

8/13/2009

Novo Nordisk
1-800-727-6500Dear Healthcare Provider Letter

Dear Patient Letter

Novolin L, Lente, human insulin zinc suspension [rDNA origin]

7/15/2003

 

Novo Nordisk Pharmaceuticals, Inc. 

Contact:
800-727-6500 Customer Service

 

Letter

NPH Iletin II (ISOPHANE INSULIN SUSPENSION, USP, PURIFIED PORK)

7/6/2005

Eli Lilly and Company

 

Opana ER strengths 7.5 mg and 15 mg3/1/2011
 Endo Pharmaceuticals Inc.
1-800-462-ENDO
(1-800-462-3636)Endo Pharmaceuticals Inc. has have made a business decision to discontinue the 7.5 mg and 15 mg strengths. The 7.5 mg and 15 mg strengths will continue to be available through pharmacies until all inventory is depleted. All other strengths remain available.
Dear Valued Customer Letter (PDF - 55KB)
 Original Prefilled Pen that Contains Humalog, Humalog Mix 75/25, and Humalog Mix 50/50updated10/26/2010Eli Lilly and CompanyBy the end of October, it is anticipated that the original Prefilled Pen containing Humalog Mix50/50 will no longer be available for ordering or shipping by wholesalers, distributors and pharmacy buyers. Supplies will be depleted by that time, and additional product will not be manufactured. At this time, the original Prefilled Pen containing Humalog or Humalog Mix75/25 continues to be available and orders will be shipped until supplies are exhausted.

 

ORLAAM (Levomethadyl hydrochloride acetate) Oral Solution, 10 mg/mL

9/2/2003

Roxane LaboratoriesLetter

Pancrease (pancrelipase) capsules

5/17/2006

McNeil Consumer and Specialty Pharmaceuticals
888-440-7903

Other pancrelipase products continue to be available

Dear Health Care Provider Letter

 

Pentothal (thiopental) Injection1/25/2011 Hospira Pharmaceuticals
1-877-946-7747Hospira has made the decision to discontinue this product.Perchloracap (potassium perchlorate) 200 mg capsules6/2/2005Tyco HealthcarePerchloracap capsules have been discontinued and supplies are anticipated to be depleted by the end of 2005.
Pontocaine HCL Injection (all products)12/9/2010
 Hospira, Inc.
1-877-946-7747

 Hospira has made a business decision to discontinue these products.
http://hospiraadvancewithus.com/

Procanbid (Procanamide Hydrochloride Extended-Release Tablets)

11/9/2007

King Pharmaceuticals 800-776-3637Dear Prescriber Letter

ProSom(estazolam) Updated

5/2/2007

Abbott
200 Abbott Park Road Abbott Park, IL 60064-6157
Customer Service: 800-633-9110Dear Health Care Provider Letter

PulmicortTurbuhaler 200mcg (budesonide inhalation powder)

5/16/2007

AztraZeneca
1800 Concord Pike PO Box 8355 Wilmington DE 19803-8355
Corporate Information:
800-842-9920

NDA 20-441, PULMICORT TURBUHALER 200 mcg (budesonide inhalation powder) will no longer be available at AstraZeneca.

The introduction of PULMICORT FLEXHALER (budesonide inhalation powder, 90 & 180 mcg), NDA 21-949, will be accompanied by the phasing out of PULMICORT TURBUHALER so as to minimize confusion in the marketplace.

AstraZeneca has no further plans to manufacture NDA 20-441, PULMICORT TURBUHALER 200 mcg (budesonide inhalation powder).

Regular Iletin II (INSULIN INJECTION, USP, PURIFIED PORK)

7/6/2005

 Eli Lilly and Company

 

Revex (Nalmefene HCl Injection) 1mg/mL, 2 mL ampule and 0.1mg/mL, 1mL ampule

7/9/2008

Baxter Healthcare Corporation
888-229-0001
 Baxter has discontinued Revex production.

Roferon-A (Interferon alfa-2a, Recombinant)

11/29/2007

Hoffmann -La Roche Inc.
800-526-6367Dear Healthcare Professional Letter

SecreFlo (porcine secretin for injection, 16 mcg/vial)

10/1/2008

ChiRhoClin, Inc., 1-877-272-4888
 Please see Dear Healthcare Professional Letter for additional information.

Serevent Inhalation Aerosol

6/10/2003

GlaxoSmithKline
800-340-3236

GSK anticipates that SEREVENT Inhalation Aerosol will no longer be available starting in June 2003.

Dear Health Care Professional Letter from GlaxoSmithKline

Sporanox (itraconazole) Injection

10/11/2007

Ortho BiotechPlease see Dear Health Care Professional letter for additional information.

Stelazine (trifluoperazine) oral concentrate 10mg/ml

Stelazine (trifluoperazine) tablets (1mg, 2mg, 5mg, 10mg)

Stelazine (trifluoperazine) Injection 2mg/ml

12/18/2003

GlaxoSmithKline
888-825-5249Stelazine was discontinued and withdrawn from the market. The final lots were distributed by GSK August 2003 and the final expiry date of all products in the marketplace is no later than January 31, 2004.

 

Suprax (cefixime)

updated 2/25/2004

Lederle/Wyeth Pharmaceuticals

Discontinued July 2002. Stock will be distributed until exhausted or until March 2003, whichever comes first.  For additional information, please call customer service (800) 666-7248

Lupin Pharmaceuticals recently received approval for cefixime 400 mg tablets and cefixime 100 mg/5 ml suspension. For further information, please contact Lupin Pharmaceuticals at 410-576-2000 (2/25/2004)

Tenormin (atenolol) 0.5mg/ml Injection

2/28/2008

AstraZeneca Pharmaceuticals LP (AstraZeneca) – Contact Corporate Information Center:
800-236-9933AstraZeneca has made a business decision to discontinue Tenormin (atenolol) 0.5 mg/ml injection.

Teslac (testolactone tablets, USP) 50mg tablets

2/26/2008

Bristol-Myers Squibb
609-897-2412

Bristol-Myers Squibb Company has made a decision to discontinue Teslac (testolactone tablets, USP) 50mg tablets.  

Letter from Bristol-Myers Squibb

Tequin (gatifloxacin) Tablets and Injection

5/12/2006

Bristol-Meyers Squibb
 See attached letter

Tilade Inhaler (nedocromil sodium inhalation aerosol)

5/2/2008

King Pharmaceuticals
800-776-3637Dear Healthcare Professional Letter (4/30/2008)

Valstar (valrubicin) Solution for Intravesical Instillation

1/30/2004

Formerly distributed by Celltech
Celltech Customer Service
888-963-3382
 No further availability planned at this time.

Velosulin BR Human, Buffered Regular Human Insulin Injection [rDNA origin]

11/3/2003
 

Novo Nordisk Pharmaceuticals, Inc.
Contact:
800-727-6500
Customer Service

 

Dear Healthcare Professional Letter

Vesanoid (tretinoin) Soft Gelatin Capsule 10 mg

12/17/2009

Hoffmann-La Roche Inc

Please see the Dear Customer Letter titled: Vesanoid 10mg (tretinoin) Product Deletion at: Vesanoid

Teva is increasing supply of their tretinoin 10mg capsules to meet market demand (NDC 00555-0808-02).

Videx (didanosine) chewable/dispersable buffered tablets

9/19/2006

BMSDear Healthcare Professional Letter
 

1.5% Xylocaine -MPF with Dextrose 7.5% Injection (lidocaine HCl and dextrose anhydrous Injection ampules) 

8/29/2005

 

AstraZeneca
800-842-9920

 

1.5% Xylocaine® -MPF with Dextrose 7.5% Injection is no longer available at AstraZeneca. The remaining inventory of 1.5% Xylocaine® -MPF with Dextrose 7.5% Injection Ampules will be depleted by August 31, 2005. AstraZeneca has no further plans to manufacture 1.5% Xylocaine® -MPF with Dextrose 7.5% Injection Ampules
 

Zenapax (daclizumab) sterile Concentrate for Injection

12/18/2009

Hoffman-La RochePlease see Dear Healthcare Professional Letter for additional information

Zovirax (acyclovir sodium) for injection 1000mg/20ml vial

1/6/2004

GlaxoSmithKline 
Customer Service
800-877-1158
 Letter from GSK

Zyflo (zileuton) tablets

2/20/2008

Critical Therapeutics, Inc.

Zyflo CR continues to be available.

Dear Healthcare Professional Letter

Read more http://www.fda.gov/Drugs/DrugSafety/DrugShortages/ucm050794.htm#mebaral

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